Due to the oxidation process, there is a natural limit to how effective the Guaiac method for diagnosing bowel cancer can be. Cross-reactions with non-specific oxidases in food - especially likely if the patient has not complied with dietary instructions - lead to an inaccurate and therefore unreliable result.
With immoCARE-C - a testing method for the detection of human haemoglobin in stool samples based on sensitive antibodies - eating restrictions are no longer necessary, either before or during the testing period. This achieves greater compliance along with improved accuracy. Clinical trials have shown that by lowering the required level of evidence (i.e. the amount of haemoglobin present in the stool) the success rate of polyp detection more than doubles.
This makes it a particularly effective testing method for early detection.
The sampling of the stool using a buffer in a pre-filled sample container is more hygienic and user-friendly. The tip of the container is broken off and some of the sample mixture placed on the sample field of the test cassette. The result (purple lines) is easy to read in the result field, and is no longer influenced by the color of the stool itself.
Advantages:
• Result visible in only 5 minutes
• immoCARE-C detects exclusively human haemoglobin
• Simple evaluation according to positive/negative principle
• No false results due to dietary influences
• Doubled PPV*
• Doubled diagnostic sensitivity*
* in comparison with the Guaiac method
New packaging
The user-friendly packaging for hospitals and clinics enables the user to remove the test components for the laboratory and ward respectively with one movement. One part of the packaging contains the test cassette for evaluation; the other contains the sample container and patient information, which can be easily given to the patient.
Is the sample bottle for stool collection appropriate only for one-time or also for repeated (3x) sampling?
Several studies were carried out in the past to verify the optimal and statistically reliable number of stool samples. A study which was conducted in Germany with hemoCARE (our Guajak-Test) and 20,000 patients supported the importance of repeated sampling. We recommend triple sampling with one and the same sampling container, which means three stool samples on three consecutive days (or three consecutive defecations) collected in one sampling container to consider the possibility of bleeding on a daily basis.
Are faint lines in the result window to be evaluated as positive?
Two violet lines in the result window are visible in case of a positive result. Thereby, it must be considered that the test line may be vary in intensity. The intensity depends on the quantity of human haemoglobin in the sample. Therefore, also a very faint test lines have to be regarded as positive.
Are there any dietary requirements to be considered?
immoCARE-C is a considerably improved and more sensitive mehtod with antibodies for detecting human haemoglobin. Thus, in comparison to common methodologies, special dietary requirements do not have to be considered. Nevertheless, it is recommended - in the days before and during sampling - to consume preferably fibre-rich food to eventually stimulate bleeding-sources.
When must immoCARE-C not be used?
• during menstrual bleeding and 3 days after
• in case of diarrhoea
• in the event of bleeding hemorrhoids
